Anti-PTH monoclonal antibody, clone FQS9591

Objective: The aim of the present study was to evaluate whether arterial stiffness is affected in the patients with hypoparathyroidism through pulse wave analysis (PWA). Subjects and methods: Sixty-three patients diagnosed with hypoparathyroidism and sixty volunteers were evaluated for the study. When 21 patients were excluded in the hypoparathyroidism group due to exclusion criteria, the research continued with 42 patients and 60 volunteers who are similar to the patients in terms of age, gender and body mass index (BMI). Fasting plasma glucose after 10 hours of fasting, creatinine, thyroid stimulating hormone (TSH), free thyroxine (fT4), albumin, calcium, phosphorus, magnesium, 25-OH vitamin D, parathormone (PTH) and urine calcium results in 24-hour urine for the patients in the hypoparathyroidism group were recorded. Evaluation of arterial stiffness was performed by Mobil-O-Graph 24h PWA device. Results: Systolic blood pressure (SBP) (p = 0.01), diastolic blood pressure (DBP) (p = 0.005), mean blood pressure (p = 0.009), central SBP (p = 0.004), central DBP (p = 0.01) and pulse wave velocity (PWV) (p = 0.02) were found higher in the hypoparathyroidism group. A positive correlation was detected between phosphorus level and SBP [(p = 0.03. r = 0.327)], central SBP [(p = 0.04, r = 0.324)] and PWV [(p = 0.003, r = 0.449)]. We detected that age and serum phosphorus levels were independent predictor variables for PWV (B = 0.014, p < 0.001 and B = 0.035, p < 0.001, respectively). Conclusion: We detected that hypoparathyroidism causes an increase in blood pressure and arterial stiffness. The most significant determinant factors were detected as advanced age and hyperphosphatemia. The patients diagnosed with hypoparathyroidism should be closely monitored and treatment planning should include to prevent the patients from hyperphosphatemia.

Background. Obesity is an endemic disease and obese people requires larger vitamin D intakes to achieve normal 25(OH)(2)D-3 as compared to individuals with normal weight. This study assessed the association of vitamin D levels with the single nucleotide polymorphism (SNPs) of genes related to obesity and vitamin D (i.e., TaqI, BsmI, Apa1, DHCR7, GC, CYP27B1 and CYP24A1). Methods. One hundred forty two women were involved in this study. The study tools included interview questionnaire, anthropometric measurements (height, weight, BMI) and blood biochemical tests (glucose, insulin, cholesterol, triglyceride, HDL, LDL, 25-Hydroxyvitamin D and parathyroid assessment and SNP analysis (VDR SNPs, DHCR7, GC, CYP27B1, CYP24A1). Results. As compared to normal vitamin D obese (NVD) subjects the weight, body mass index (BMI) and parathyroid hormone (PTH) was significantly higher in vitamin D deficient obese (VDD) subjects. While, total cholesterol (TC), triglyceride (TG) and vitamin D levels were significantly lower in the vitamin D deficient group compared to the normal vitamin D group. Various variants such as TaqI, BsmI, Apa1, DHCR7, GC rs4588 and CYP27B1 did not showed any significant association with the pathogenesis of vitamin D deficiency related obesity. However, GC rs7041 and CYP24A1 genotypes were significantly related with vitamin D deficiency in patients with obesity. Conclusion. This study suggests that polymorphisms in the GC and CYP24A1 genes are related with vitamin D deficiency in obese females. These polymorphisms may become a useful marker to predict the impending development of vitamin D deficiency in obese females. Studies have revealed that associations between genotypes of these SNPs and particular phenotypes may vary according to the following: ethnicity, interactions with environmental factors, sex, and number of participants.