Anti-PTEN monoclonal antibody (DCABH-5517) Knockout Validated

Rabbit anti-Human PTEN monoclonal antibody for IHC-P, WB, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS0052-3
Species Reactivity
Mouse, Rat, Human
Immunogen
Recombinant fragment within Human PTEN aa 1 to the C-terminus. The exact sequence is proprietary.Database link: P60484
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/50 - 1/100; WB: 1/1000 - 1/5000; ICC/IF: 1/100 - 1/250.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PTEN; phosphatase and tensin homolog; BZS, MHAM; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; MMAC1; mutated in multiple advanced cancers 1
Entrez Gene ID
UniProt ID

Product Background


Pathway
3-phosphoinositide degradation, organism-specific biosystem; 3-phosphoinositide degradation, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, organism-specific biosystem;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Wang, QF; Ding, H; et al. Addition of the Akt inhibitor triciribine overcomes antibody resistance in cells from ErbB2/Neu-positive/PTEN-deficient mammary tumors. INTERNATIONAL JOURNAL OF ONCOLOGY 44:1277-1283(2014).
Lan, KH; Lu, CH; et al. Mechanisms of trastuzumab resistance and their clinical implications. TUMOR PROGRESSION AND THERAPEUTIC RESISTANCE 1059:70-75(2005).

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