Human PTEN blocking peptide

Product Overview

PTEN ( internal ) peptide ( human )

Target

PTEN

Nature

Synthetic

Tag/Conjugate

Unconjugated

Concentration

0.2 mg/ml

Buffer

Preservative: 0.1% Sodium Azide; Constituents: PBS, BSA

Preservative

0.1% Sodium Azide

Storage

Store this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment.

Entrez Gene ID

Antigen Description

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]

Function

PDZ domain binding; anaphase-promoting complex binding; enzyme binding; hydrolase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; magnesium ion binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; p

Synonyms

PTEN; phosphatase and tensin homolog; BZS, MHAM; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; MMAC1; mutated in multiple advanced cancers 1; PTEN1; TEP1; phosphatase and tensin-like protein; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; BZS; DEC; GLM2; MHAM; 10q23del; MGC11227;