Anti-PSMA6 monoclonal antibody, clone 5D0

Antibody Isotype

IgG2b

Clone

5D0

Species Reactivity

Mouse; Rat; Dog; Human; Monkey

Immunogen

Recombinant full length Human Proteasome subunit alpha type 6 produced in E.coli (NP_002782).

Conjugate

Application Notes

WB: 1/500 - 1/2000; IHC-P: 1/150; Flow Cyt: 1/100;

Alternative Names

PSMA6; proteasome (prosome, macropain) subunit, alpha type, 6; proteasome subunit alpha type-6; IOTA; MGC2333; MGC22756; MGC23846; p27K; PROS27; PROS-27; macropain iota chain; prosomal P27K protein; proteasome iota chain; macropain subunit iota; 27 kDa pr

Entrez Gene ID

UniProt ID

Antigen Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem;