Anti-PSMA4 monoclonal antibody, clone 2I21

Antibody Isotype

IgG1

Clone

2I21

Species Reactivity

Mouse; Rat; Human; Monkey

Immunogen

Recombinant full length Human PSMA4 produced in HEK293T cells (NP_002780).

Conjugate

Application Notes

WB: 1/500 - 1/2000; IHC-P: 1/150;

Alternative Names

PSMA4; proteasome (prosome, macropain) subunit, alpha type, 4; proteasome subunit alpha type-4; HC9; HsT17706; macropain subunit C9; proteasome subunit L; proteasome subunit HC9; proteasome component C9; multicatalytic endopeptidase complex subunit C9; PS

Entrez Gene ID

UniProt ID

Antigen Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem;