Anti-PRKACA (aa 1-120) polyclonal antibody

Species Reactivity

Human

Immunogen

PRKACA (AAH39846, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. The sequence is MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV

Conjugate

Alternative Names

PRKACA; protein kinase, cAMP-dependent, catalytic, alpha; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; protein kinase A catalytic subunit; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1;

Entrez Gene ID

UniProt ID

Antigen Description

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Pathway

Activation of NMDA receptor upon glutamate binding and postsynaptic events; Adrenergic signaling in cardiomyocytes; Alcoholism; Amoebiasis