Anti-PRKACA Monoclonal antibody, clone FQ3203Z

Antibody Isotype

IgG

Clone

FQ3203Z

Species Reactivity

Human; Mouse; Rat

Immunogen

A synthetic peptide corresponding to residues near the C-terminus of human PRKACA was used as immunogen.

Conjugate

Application Notes

WB: 1:100000-200000; IHC: 1:100

Alternative Names

PRKACA; protein kinase, cAMP-dependent, catalytic, alpha; cAMP-dependent protein kinase catalytic subunit alpha; PKACa; PKA C-alpha; protein kinase A catalytic subunit; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; PKACA; MGC48865; MGC

Entrez Gene ID

UniProt ID

Antigen Description

PKA (or cAPK) is a cyclic AMP-dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, and gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C-alpha, C-beta, and C-gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Studies have shown the importance of PKA phosphorylation at Thr 197 regards to PKA maturation, optimal conformation, and catalytic activity.

Pathway

Adaptive Immune System, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem.