Specifications
Immunogen
Synthetic peptide: C-ERSNLPTDASTTA, corresponding to internal sequence amino acids 1514-1526 of Human PREX1 (NP_065871.2).
Applications
Application Notes
WB: 1 - 3 μg/ml.
Target
Alternative Names
PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; KIAA1415; P REX1; ptdIns(3,4,5)-dependent Rac exchanger 1; P-REX1;
Product Background
Antigen Description
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Pathway
Cell death signalling via NRAGE, NRIF and NADE; Chemokine signaling pathway; Class I PI3K signaling events; G alpha (12/13) signalling events; GPCR downstream signaling; NRAGE signals death through JNK;
Citations
Publication ()
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COA
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