Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.
Pathway
Activation of Chaperone Genes by XBP1(S); Activation of Chaperones by IRE1alpha; Asparagine N-linked glycosylation; COPII (Coat Protein 2) Mediated Vesicle Transport; Diabetes pathways; Disease; ER to Golgi Transport
Citations
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