Recombinant fragment, corresponding to a region within amino acids 95-272 of Human GADD34 (O75807).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/3000. ICC/IF: 5 μg/ml.
Target
Alternative Names
PPP1R15A; protein phosphatase 1, regulatory subunit 15A; GADD34; protein phosphatase 1 regulatory subunit 15A; growth arrest and DNA-damage-inducible 34; growth arrest and DNA damage-inducible protein GADD34; protein phosphatase 1, regulatory (inhibitor)
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on Ser-15.
Pathway
BMP receptor signaling; Downregulation of TGF-beta receptor signaling; Loss of Function of SMAD4 in Cancer; Loss of Function of TGFBR2 in Cancer
Citations
Publication ()
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COA
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