Anti-PLA2R1 (aa 946-957) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Dog; Human

Immunogen

Synthetic peptide: C-EKKKDTPKQHGT, corresponding to internal sequence amino acids 946-957 of Human PLA2R (NP_031392.3; NP_001007268.1).

Conjugate

Application Notes

WB: 1 - 3 μg/ml;

Alternative Names

PLA2R1; phospholipase A2 receptor 1, 180kDa; PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R; secretory phospholipase A2 receptor; M-type receptor; phospholipase A2 receptor 1, 180kD; C-type lectin domain family 13 member C; 180 kDa secretory phospholipase A2 rec

Entrez Gene ID

UniProt ID

Antigen Description

PLA2R is a receptor for secretory phospholipase A2 (sPLA2). It acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, and selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. PLA2R may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. [Swiss-Prot]

Pathway

Phagosome; Tuberculosis;