Product Overview
Blocking/Immunizing peptide for anti-PLA2R1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Function
carbohydrate binding; phospholipase binding; phospholipase binding; receptor activity;
Synonyms
PLA2R1; phospholipase A2 receptor 1, 180kDa; PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R; secretory phospholipase A2 receptor; M-type receptor; C-type lectin domain family 13 member C; 180 kDa secretory phospholipase A2 receptor;
Citations
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Ronco, P; Debiec, H; et al. Idiopathic and secondary membranous nephropathies. PRESSE MEDICALE 41:290-297(2012).
Beck, LH; et al. Anti-Phospholipase A(2) Receptor-1 Autoantibodies and Membranous Nephropathy. PODOCYTOPATHY 183:132-144(2014).