Anti-PIK3C2B (aa 1-110) polyclonal antibody

Species Reactivity

Human

Immunogen

PIK3C2B (NP_002637, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. The sequence is MSSTQDNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISW DEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQG

Conjugate

Alternative Names

PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; C2-PI3K; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; PI3K-C2beta; PI3K-C2-beta; PTDINS-3-kinase C2 beta; ptdIns-3-kinase C2 subunit beta; p

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.

Pathway

3-phosphoinositide biosynthesis; Inositol phosphate metabolism; Metabolism of lipids and lipoproteins; Phosphatidylinositol signaling system