Anti-PIGS monoclonal antibody, clone 4G4

Antibody Isotype

IgG2b

Clone

4G4

Species Reactivity

Human; Mouse

Immunogen

PIGS (NP_149975.1, 450 a.a. ~ 518 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

PIGS; phosphatidylinositol glycan anchor biosynthesis, class S; phosphatidylinositol glycan, class S; GPI transamidase component PIG-S; GPI transamidase subunit; phosphatidylinositol-glycan biosynthesis class S protein; FLJ45226; DKFZp686K20216;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.

Pathway

Attachment of GPI anchor to uPAR, organism-specific biosystem; Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, organism-specific biosystem; Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem;