Anti-PICK1 (aa 266-375) polyclonal antibody

Species Reactivity

Human

Immunogen

PRKCABP (NP_036539, 266 a.a. ~ 375 a.a) partial recombinant protein with GST tag. The sequence is KVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQK HVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGLNQ

Conjugate

Alternative Names

PICK1; protein interacting with PRKCA 1; PICK; PRKCABP; PRKCA-binding protein; protein interacting with C kinase 1; protein kinase C-alpha-binding protein;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

Pathway

Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity; Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell; Trafficking of GluR2-containing AMPA receptors;