Anti-PIAS2 monoclonal antibody, clone QJBTY-227

Antibody Isotype

IgG1

Clone

QJBTY-227

Species Reactivity

Human

Immunogen

Synthetic peptide: AGRNKSGRKHDLLMR, corresponding to amino acids 26/40 of Human PIAS2

Conjugate

Application Notes

WB: 1 - 2 μg/ml; ICC/IF: 20 μg/ml;

Alternative Names

PIAS2; protein inhibitor of activated STAT, 2; E3 SUMO-protein ligase PIAS2; miz; PIASX ALPHA; PIASX BETA; zinc finger; MIZ type containing 4; ZMIZ4; DAB2-interacting protein; zinc finger, MIZ-type containing 4; msx-interacting zinc finger protein; protei

Entrez Gene ID

UniProt ID

Antigen Description

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; IL12 signaling mediated by STAT4, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Pathways in cancer, organism-specific biosystem;