PIAS2 blocking peptide (CDBP5912)

Synthetic PIAS2 blocking peptide for IB Datasheet

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Nature
Synthetic
Immunogen
18 amino acids near the amino terminus of human PIAS2.
Species Reactivity
Mouse, rat, human
Tag/Conjugate
Unconjugated
Format
Liquid
Concentration
200 μg/mL
Size
0.05mg
Storage
-20°C
UniProt ID
Antigen Description
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]
Function
DNA binding; SUMO ligase activity; androgen receptor binding; protein binding; transcription coactivator activity; ubiquitin protein ligase binding; zinc ion binding
Synonyms
PIAS2; protein inhibitor of activated STAT, 2; DIP; MIZ; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4; PIASX-BETA; PIASX-ALPHA; E3 SUMO-protein ligase PIAS2; DAB2-interacting protein; zinc finger, MIZ-type containing 4; msx-interacting zinc finger protein; protein inhibitor of activated STAT X; androgen receptor-interacting protein 3

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