General Notes
This product (Catalog No. DPABH-15011) is a rabbit-derived polyclonal antibody raised against human PDGFRB, targeting the amino acid region 33–530 of the protein. This antibody exhibits cross-reactivity with Human PDGFRB from mouse and rat. It has been affinity purified by Protein A. PDGFRB is a gene located on chromosome 5q32 that encodes platelet-derived growth factor receptor beta (PDGFRβ), a transmembrane receptor tyrosine kinase that binds members of the platelet-derived growth factor (PDGF) family to regulate critical cellular processes including proliferation, migration, differentiation, and survival, particularly in mesenchymal-derived cells and vascular structures. The PDGFRβ protein consists of an extracellular domain with five immunoglobulin-like domains for ligand binding, a single transmembrane helix, and an intracellular tyrosine kinase domain that, upon PDGF-induced dimerization (primarily PDGF-BB homodimers), autophosphorylates and activates downstream signaling pathways such as PI3K/AKT and MAPK/ERK, which control cytoskeletal reorganization and gene expression. Expressed widely in pericytes, fibroblasts, and smooth muscle cells, PDGFRβ plays a pivotal role in embryonic development of the cardiovascular system, including blood vessel formation and blood-brain barrier integrity, as evidenced by pericyte-deficient mouse models exhibiting microaneurysms and barrier defects.
DPABH-15011 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-15011 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
COA
Publication 
Loading ......
