Alternative Names
PDGFRB; platelet-derived growth factor receptor, beta polypeptide; JTK12; PDGFR; CD140B; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; CD140 antigen-like family member B; EC 2.7.10.1; CD140b; PDGF-R-beta; CD140b antigen; soluble PDGFR
Antigen Description
Platelet-derived growth factors (PDGFs) have been implicated in the control of cell proliferation, survival and migration. The PDGF family of growth factors consists of five different disulphide-linked dimers built up of four different polypeptide chains encoded by four different genes. Theses isoforms, PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD, act via two receptor tyrosine kinases, PDGF receptors α and β. Thus far, gene-targeting experiments have been attempted to create knockout mice deficient for PDGFR-α or PDGFR-β. Those mice, however, died either at the embryonic stage or several days after birth. Platelet-derived growth factor receptors, PDGFR-α and PDGFR-β, have five extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo- and heterodimers.
Pathway
Calcium signaling pathway; Cytokine-cytokine receptor interaction; Focal adhesion; Gap junction; Glioma; HTLV-I infection; MAPK signaling pathway; Melanoma; Nectin adhesion pathway; Osteoblast Signaling; PDGFR-beta signaling pathway; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; S1P1 pathway
COA
Publication 
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