This gene encodes a cell surface tyrosine kinase receptorfor members of the platelet-derived growth factor family. Thesegrowth factors are mitogens for cells of mesenchymal origin. Theidentity of the growth factor bound to a receptor monomerdetermines whether the functional receptor is a homodimer or aheterodimer, composed of both platelet-derived growth factorreceptor alpha and beta polypeptides. This gene is flanked onchromosome 5 by the genes for granulocyte-macrophagecolony-stimulating factor and macrophage-colony stimulating factorreceptor; all three genes may be implicated in the 5-q syndrome. Atranslocation between chromosomes 5 and 12, that fuses this gene tothat of the translocation, ETV6, leukemia gene, results in chronicmyeloproliferative disorder with eosinophilia. [provided byRefSeq].
Pathway
Adaptive Immune System; Calcium signaling pathway; Constitutive PI3K/AKT Signaling in Cancer; Cytokine-cytokine receptor interaction; DAP12 interactions; DAP12 signaling; Disease; Downstream Signaling Events Of B Cell Receptor (BCR);
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