Anti-PARP1 monoclonal antibody, clone 5C6CE3 [Alexa Fluor® 488]

Antibody Isotype

IgG1

Clone

5C6CE3

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to Human Cleaved PARP aa 215-228 (N terminal).Sequence: GVDEVAKKKSKKEKC Database link: P09874

Conjugate

Application Notes

ICC: 1 μg/ml; Flow Cyt: 1 μg/ml.

Alternative Names

PARP1; poly (ADP-ribose) polymerase 1; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) , ADPRT, poly (ADP ribose) polymerase family, member 1 , PPOL; poly [ADP-ribose] polymerase 1; PARP; poly(ADP-ribose) polymerase; poly(ADP-ribose) syntheta

Entrez Gene ID

UniProt ID

Antigen Description

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150.

Pathway

BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Caspase cascade in apoptosis, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem;