Anti-PARP1 monoclonal antibody (DCABH-316)

Mouse anti-Human PARP1 monoclonal antibody for WB, IP, ELISA, IHC-P, IHC-Fr Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
B7.5.23
Species Reactivity
Human
Immunogen
Native Human PARP protein.
Conjugate
Unconjugated

Applications


Application Notes
ELISA: 1/1000 - 1/5000; IHC-P: 10 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PARP1; poly (ADP-ribose) polymerase 1; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) , ADPRT, poly (ADP ribose) polymerase family, member 1 , PPOL; poly [ADP-ribose] polymerase 1; PARP
Entrez Gene ID
UniProt ID

Product Background


Pathway
BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Caspase cascade in apoptosis, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem;

Citations


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References


Redon, CE; Nakamura, AJ; et al. Histone yH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers. CLINICAL CANCER RESEARCH 16:4532-4542(2010).
Meng, XW; Koh, BD; et al. Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20543-20558(2014).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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