Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
Pathway
ADP signalling through P2Y purinoceptor 1; G alpha (q) signalling events; GPCR ligand binding; Gastrin-CREB signalling pathway via PKC and MAPK
Citations
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