The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Pathway
Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; Assembly of the pre-replicative complex; CDC6 association with the ORC:origin complex; CDT1 association with the CDC6:ORC:origin complex; Cell Cycle; Cell Cycle Checkpoints; Cell Cycle, Mitotic; DNA Replication; DNA Replication Pre-Initiation;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Xi, Y; Formentini, A; et al. Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer. ONCOLOGY REPORTS 19:257-262(2008).
Song, QX; Jing, H; et al. Gene expression analysis on a photodiode array-based bioluminescence analyzer by using sensitivity-improved SRPP. ANALYST 135:1315-1319(2010).
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