Anti-NRAS (aa 90-189) polyclonal antibody

Species Reactivity

Human

Immunogen

NRAS (AAH05219, 90 a.a. ~ 189 a.a) partial recombinant protein with GST tag. The sequence is FADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTR QGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM

Conjugate

Alternative Names

NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog; NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1; GTPase NRas; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog;

Entrez Gene ID

UniProt ID

Antigen Description

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Pathway

ARMS-mediated activation; Acute myeloid leukemia; Adaptive Immune System; Alcoholism