Anti-NR2C1 monoclonal antibody, clone 5F5

Antibody Isotype

IgG2a

Clone

5F5

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to Human TR2-11 aa 1-237. NP_001027458 produced in E.coli.Sequence: MATIEEIAHQIIEQQMGEIVTEQQTGQKIQIVTALDHNTQGKQFILTNHD GSTPSKVILARQDSTPGKVFLTTPDAAGVNQLFFTTPDLSAQHLQLLTDN SPDQGPNKVFDLCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCR

Conjugate

Application Notes

WB: 1/2000;

Alternative Names

NR2C1; nuclear receptor subfamily 2, group C, member 1; TR2; nuclear receptor subfamily 2 group C member 1; TR2 11; orphan nuclear receptor TR2; TR2 nuclear hormone receptor; nuclear receptor subfamily 2, group C isoform;

Entrez Gene ID

UniProt ID

Antigen Description

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5-AGGTCA-3 half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.

Pathway

Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem;