Anti-NR0B1 (aa 361-470) polyclonal antibody

Species Reactivity

Human

Immunogen

NR0B1 (NP_000466, 361 a.a. ~ 470 a.a) partial recombinant protein with GST tag. The sequence is IKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQ GPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI

Conjugate

Alternative Names

NR0B1; nuclear receptor subfamily 0, group B, member 1; AHC; AHX; DSS; GTD; HHG; AHCH; DAX1; DAX-1; NROB1; SRXY2; nuclear receptor subfamily 0 group B member 1; nuclear receptor DAX-1; nuclear hormone receptor; DSS-AHC critical region on the X chromosome

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.

Pathway

Gene Expression; Nuclear Receptor transcription pathway; Regulation of Androgen receptor activity;