Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Pathway
AGE/RAGE pathway; Activated TLR4 signalling; Activation of NF-kappaB in B Cells; Adaptive Immune System; Adipocytokine signaling pathway; Apoptosis; Apoptosis Modulation and Signaling; Atypical NF-kappaB pathway;
Citations
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