This product (Catalog No. DPABH-13090) is a rabbit-derived polyclonal antibody raised against human NF1. This antibody exhibits cross-reactivity with NF1 from mouse and rat. It has been affinity purified by Protein A. This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. DPABH-13090 is suitable for use in Western blot (WB) (1:200–1:1,000), IHC (1:20–1:100) applications. DPABH-13090 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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