NF1 (NP_000258, 2719 a.a. ~ 2818 a.a) partial recombinant protein with GST tag. The sequence is DTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENV ELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV
Conjugate
Unconjugated
Target
Alternative Names
NF1; neurofibromin 1; WSS; NFNS; VRNF; neurofibromin; neurofibromatosis-related protein NF-1;
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
Pathway
ATF-2 transcription factor network; Integrated Breast Cancer Pathway; Ras signaling pathway; Syndecan-2-mediated signaling events
Citations
Publication ()
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