Rabbit Anti-Human NEDD4L (C-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Fusion protein corresponding to residues near the C terminal of human neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Conjugate

Application Notes

IHC: 1:100-1:300

General Notes

This product (Catalog No. DPABH-17505) is a rabbit-derived IgG polyclonal antibody raised against human NEDD4L. This antibody exhibits cross-reactivity with NEDD4L from mouse. It has been affinity purified by protein A. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
DPABH-17505 is suitable for use in IHC (1:100–1:300) application.
DPABH-17505 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

RSP5; NEDD4-2; NEDD4.2; hNEDD4-2

Entrez Gene ID

UniProt ID