Magic™ Anti-NEDD4-2 (Phospho S448) monoclonal antibody, clone FQS9370(3)

Antibody Isotype

IgG

Clone

FQS9370(3)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to Human NEDD4-2 (phospho S448). Corresponding to residues surrounding Serine 448.Database link: Q96PU5

Conjugate

Application Notes

WB: 1/1000 - 1/5000; IP: 1/10 - 1/100

Alternative Names

NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down regulated 4 like; E3 ubiquitin-protein ligase NEDD4-like; KIAA0439; NEDD4 2; RSP5; ubiquitin

Entrez Gene ID

UniProt ID

Antigen Description

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.

Pathway

Adaptive Immune System, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem;