Anti-NDEL1 monoclonal antibody, clone FQS6179

Antibody Isotype

IgG

Clone

FQS6179

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues near the N-terminus of Human Nudel. (Uniprot: Q9GZM8)

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100;

Alternative Names

NDEL1; nudE nuclear distribution E homolog (A. nidulans)-like 1; nudE nuclear distribution gene E homolog (A. nidulans) like 1; nuclear distribution protein nudE-like 1; MITAP1; NUDEL; protein Nudel; endooligopeptidase A; mitosin-associated protein 1; mit

Entrez Gene ID

UniProt ID

Antigen Description

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Pathway

Aurora A signaling, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem;