Anti-MSH6 (aa 931-1030) polyclonal antibody

Species Reactivity

Human

Immunogen

MSH6 (NP_000170, 931 a.a. ~ 1030 a.a) partial recombinant protein with GST tag. The sequence is AGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNL PEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLK

Conjugate

Alternative Names

MSH6; mutS homolog 6; GTBP; HSAP; p160; GTMBP; HNPCC5; DNA mismatch repair protein Msh6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Pathway

BRCA1-associated genome surveillance complex (BASC); Integrated Breast Cancer Pathway; Mismatch repair; Prostate Cancer