Mouse anti-Human MSH6 monoclonal antibody for IHC
ELK4 (ELK4, ETS Transcription Factor) is a Protein Coding gene. Among its related pathways are EGFR1 Signaling Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ELF4. This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.
MSH6 is a gene commonly associated with hereditary nonpolyposis colorectal cancer. MSH6 contributes to ADP and ATP binding. Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at Lys-18 (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5side of SRF, but does not bind DNA autonomously. ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene. This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. The function about ELK4 antigen include contributes_to ADP binding; contributes_to ATP binding; contributes_to ATPase activity; contributes_to MutLalpha complex bindin; chromatin binding; damaged DNA binding; contributes_to double-stranded DNA binding; contributes_to four-way junction DNA bindi.
BRCA1-associated genome surveillance complex (BASC); Colorectal cancer; Mismatch repair; Pathways in cancer.
Day, BW; Stringer, BW; et al. ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1. NEURO-ONCOLOGY 13:1202-1212(2011).
Shia, J; Klimstra, DS; et al. Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 29:96-104(2005).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.