CBARA1 (NP_006068, 380 a.a. ~ 478 a.a) partial recombinant protein with GST tag. The sequence is DTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIM KQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPKQ
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.
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