General Notes
This product (Catalog No. DPABH-22728) is a rabbit-derived polyclonal antibody raised against human MANF, targeting the amino acid region 28–182 of the protein. This antibody exhibits cross-reactivity with Human MANF from mouse and rat. It has been affinity purified by Protein A. Mesencephalic astrocyte-derived neurotrophic factor (MANF; also known as ARMET) is a small, secreted protein that acts as an endoplasmic reticulum (ER) stress-responsive factor, offering cytoprotective and regenerative effects primarily in dopamine neurons and pancreatic beta cells. Originally identified as a trophic factor derived from mesencephalic astrocytes, MANF localizes to the ER lumen and is released under stress conditions to modulate the unfolded protein response (UPR), inhibit apoptosis, and promote cell survival and proliferation.
DPABH-22728 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-22728 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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