Rabbit anti-Human LRP5 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthesized peptide derived from part region of human protein

Conjugate

Application Notes

WB: 1 μg/ml.

Alternative Names

LRP5; low density lipoprotein receptor-related protein 5; EVR1, exudative vitreoretinopathy 1; LRP7, OPPG, osteoporosis pseudoglioma syndrome; low-density lipoprotein receptor-related protein 5; BMND1; HBM; LR3; OPS; LRP-5; low density lipoprotein recepto

Entrez Gene ID

UniProt ID

Antigen Description

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

Pathway

MicroRNAs in cardiomyocyte hypertrophy; N-cadherin signaling events; Wnt Signaling Pathway NetPath; Wnt Signaling Pathway and Pluripotency; Wnt signaling network; Wnt signaling pathway;