Anti-LRP5 monoclonal antibody, clone 3C22

Antibody Isotype

IgG1

Clone

3C22

Species Reactivity

Human

Immunogen

Purified recombinant fragment of Human LRP5 expressed in E. Coli.

Conjugate

Application Notes

WB: 1/500 - 1/2000; Flow Cyt: 1/200 - 1/400;

Alternative Names

LRP5; low density lipoprotein receptor-related protein 5; EVR1, exudative vitreoretinopathy 1 , LRP7, OPPG, osteoporosis pseudoglioma syndrome; low-density lipoprotein receptor-related protein 5; BMND1; HBM; LR3; OPS; LRP-5; low density lipoprotein rece

Entrez Gene ID

UniProt ID

Antigen Description

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

Pathway

MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; N-cadherin signaling events, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem; Wnt signaling network, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem;