Anti-LCN2 polyclonal antibody (DPABY-287)

Specifications


Host Species
Goat
Antibody Isotype
IgG
Species Reactivity
Rat
Immunogen
Mouse myeloma cell line NS0-derived recombinant rat Lipocalin-2/NGAL. Gln21-Asn198 Accession Number P30152
Conjugate
Unconjugated

Applications


Application Notes
Western Blot 1 μg/mL; Immunoprecipitation 25 μg/mL ELISA Capture 0.2-0.8 μg/mL; ELISA Detection 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DPABY-287 - DPABY-426
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
LCN2; lipocalin 2; Sip24; neutrophil gelatinase-associated lipocalin; p25; NGAL
Entrez Gene ID
UniProt ID

Citations


Have you cited DPABY-287 in a publication? Let us know and earn a reward for your research.

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Anti-Goat IgG Fc polyclonal antibody [HRP] DPBT-67068RG IHC ELISA FC IP WB Rabbit PDF Inquiry
Anti-Goat IgG Fc polyclonal antibody [FITC] DPBT-67067RG IHC ELISA FC IP WB Rabbit PDF Inquiry
Anti-Goat IgG Fc polyclonal antibody [FITC] DPAB22048 IF Rabbit PDF Inquiry
Anti-Goat IgG Fc polyclonal antibody [Texas Red®] DPAB22055 IF Rabbit PDF Inquiry
Anti-Goat IgG polyclonal antibody [HRP] DPBT-67070RG IHC ELISA WB Rabbit PDF Inquiry
Anti-Goat IgG polyclonal antibody [AP] DPBT-67072RA IHC ELISA WB Rabbit PDF Inquiry
Anti-Goat IgG polyclonal antibody [Biotin] DPBT-67075DG IHC ELISA Donkey PDF Inquiry
Anti-Goat IgG polyclonal antibody DPAB2710 ELISA WB Chicken PDF Inquiry
Anti-Goat IgG F(ab)2 polyclonal antibody [TRITC] DPAB22035 IF Rabbit PDF Inquiry
Anti-Goat IgG polyclonal antibody [Texas Red®] DPAB21914 IF Donkey PDF Inquiry
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

References


Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity

ONCOTARGET

Authors: Chappell, William H.; Abrams, Stephen L.; Montalto, Giuseppe; Cervello, Melchiorre; Martelli, Alberto M.; Candido, Saverio; Libra, Massimo; Polesel, Jerry; Talamini, Renato; Arlinghaus, Ralph; Steelman, Linda S.; McCubrey, James A.

Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL expression is detected in response to various chemotherapeutic drugs including doxorubicin and docetaxel. We were interested in the roles of NGAL expression in cancer and whether it is associated with chemotherapeutic drug resistance. In the present study, we investigated whether increased NGAL expression led to resistance to the chemotherapeutic drug doxorubicin in normal breast epithelial cells (MCF-10A), breast cancer cells (MCF-7), and colorectal cancer cells (HT-29). We infected the various cell lines with a retrovirus encoding NGAL which we constructed. Increased NGAL expression was readily detected in the NGAL-infected cells but not the empty vector-infected cells. However, increased NGAL expression did not alter the sensitivity of the cells to the chemotherapeutic drug doxorubicin. Thus, although NGAL expression is often detected after chemotherapeutic drug treatment, it by itself, does not lead to doxorubicin resistance.

The neural basis of analogical reasoning: An event-related potential study

NEUROPSYCHOLOGIA

Authors: Qiu, Jiang; Li, Hong; Chen, Antao; Zhang, Qinglin

The spatiotemporal analysis of brain activation during the execution of easy analogy (EA) and difficult analogy (DA) tasks was investigated using high-density event-related brain potentials (ERPs). Results showed that reasoning tasks (schema induction) elicited a more negative ERP deflection (N500-1000) than did the baseline task (BS) between 500 and 1000 ms. Dipole source analysis of difference waves (EA-BS and DA-BS) indicated that the negative components were both localized near the left thalamus, possibly associated with the retrieval of alphabetical information. Furthermore, DA elicited more positive ERP component (P600-1000) than did EA in the same time window. Two generators of P600-1000 were located in the medial prefrontal cortex (BA10) and the left frontal cortex (BA6)which was possibly involved in integrating information in schema abstraction. In the stage of analogy mapping, a greater negativity (N400-600) in the reasoning tasks as compared to BS was found over fronto-central scalp regions. A generator of this effect was located in the left fusiform gyrus and was possibly related to associative memory and activation of schema. Then, a greater negativity in the reasoning tasks, in comparison to BS task, developed between 900-1200 ms (LNC1) and 2000-2500 ms (LNC2). Dipole source analysis (EA-BS) localized the generator of LNC1 in the left prefrontal cortex (BA 10) which was possibly related to mapping the schema to the target problem, and the generator of LNC2 in the left prefrontal cortex (BA 9) which was possibly related to deciding whether a conclusion Correctly follows from the schema. (C) 2008 Elsevier Ltd. All rights reserved.

Online Inquiry

Name:
Phone: *
E-mail Address: *
Technology Interest:
Type of Organization:
Service & Products Interested: *
Project Description:

Related Products

Related Resources

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

Inquiry Basket