Anti-LBP monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human LBP is used for rabbit immunization.

Conjugate

Alternative Names

LBP; lipopolysaccharide binding protein; lipopolysaccharide-binding protein; BPI fold containing family D; member 2; BPIFD2; LPS-binding protein; BPI fold containing family D, member 2; MGC22233;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.

Pathway

IL6-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; LPS transferred from LBP carrier to CD14, organism-specific biosystem; Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem; Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem;