Anti-KREMEN2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human KREMEN2 is used for rabbit immunization.

Conjugate

Alternative Names

KREMEN2; kringle containing transmembrane protein 2; kremen protein 2; KRM2; MGC10791; dickkopf receptor 2; kringle domain-containing transmembrane protein 2; kringle-containing protein marking the eye and the nose; MGC16709;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Pathway

Presenilin action in Notch and Wnt signaling, organism-specific biosystem; Wnt signaling network, organism-specific biosystem;