Antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1.
Conjugate
Unconjugated
Target
Alternative Names
KREMEN1; kringle containing transmembrane protein 1; KRM1; KREMEN; kremen protein 1; dickkopf receptor; kringle-coding gene marking the eye and the nose; kringle domain-containing transmembrane protein 1; kringle-containing protein marking the eye and the
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Pathway
Disease; RNF mutants show enhanced WNT signaling and proliferation; Signal Transduction; Signaling by WNT in cancer; Signaling by Wnt; TCF dependent signaling in response to WNT; Wnt signaling network; XAV939 inhibits tankyrase
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COA
Certificate of Analysis
