KREMEN1 (NP_114434, 310 a.a. ~ 391 a.a) partial recombinant protein with GST tag. The sequence is INQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHP PQTVPGSNSWAPPMGAGSHRVE
Conjugate
Unconjugated
Target
Alternative Names
KREMEN1; kringle containing transmembrane protein 1; KRM1; KREMEN; kremen protein 1; dickkopf receptor; kringle-coding gene marking the eye and the nose; kringle domain-containing transmembrane protein 1; kringle-containing protein marking the eye and the
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Pathway
Signal Transduction; TCF dependent signaling in response to WNT; negative regulation of TCF-dependent signaling by WNT ligand antagonists.
Citations
Publication ()
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