Anti-KLF4 (aa 1-212) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to a region within amino acids 1-212 of KLF4 (O43474; NP_004226).

Conjugate

Application Notes

WB: 1/500 - 1/3000; ICC/IF: 1/100 - 1/1000.

Alternative Names

KLF4; Kruppel-like factor 4 (gut); Krueppel-like factor 4; EZF; GKLF; gut-enriched krueppel-like factor; epithelial zinc finger protein EZF; endothelial Kruppel-like zinc finger protein;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor; can act both as activator and as repressor. Binds the 5-CACCC-3 core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Pathway

Developmental Biology; Diabetes pathways; Disease; Regulation of Wnt-mediated beta catenin signaling and target gene transcription; Synthesis, Secretion, and Deacylation of Ghrelin; Transcriptional Regulation of White Adipocyte Differentiation;