Anti-KLF4 monoclonal antibody, clone 2F7

Antibody Isotype

IgG1

Clone

2F7

Species Reactivity

Human

Immunogen

Purified recombinant fragment of Human KLF4 expressed in E. coli.

Conjugate

Application Notes

WB: 1/500 - 1/2000; IHC-P: 1/200 - 1/1000; ICC/IF: 1/200 - 1/1000; Flow Cyt: 1/50 - 1/1000;

Alternative Names

KLF4; Kruppel-like factor 4 (gut); Krueppel-like factor 4; EZF; GKLF; gut-enriched krueppel-like factor; epithelial zinc finger protein EZF; endothelial Kruppel-like zinc finger protein;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor; can act both as activator and as repressor. Binds the 5-CACCC-3 core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Pathway

Developmental Biology, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Synthesis, Secretion, and Deacylation of Ghrelin, organism-specific biosystem; Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem;