Anti-KCNJ2 (aa 328-427) polyclonal antibody

Species Reactivity

Human

Immunogen

KCNJ2 (NP_000882, 328 a.a. ~ 427 a.a) partial recombinant protein with GST tag. The sequence is PVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEE DDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI

Conjugate

Alternative Names

KCNJ2; potassium inwardly-rectifying channel, subfamily J, member 2; IRK1; LQT7; SQT3; ATFB9; HHIRK1; KIR2.1; HHBIRK1; inward rectifier potassium channel 2; IRK-1; hIRK1; inward rectifier K+ channel KIR2.1; cardiac inward rectifier potassium channel;

Entrez Gene ID

UniProt ID

Antigen Description

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.

Pathway

Activation of G protein gated Potassium channels; Cholinergic synapse; G protein gated Potassium channels; GABA receptor activation