Anti-KCNJ2 monoclonal antibody, clone L

Antibody Isotype

IgG

Clone

L

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide corresponding to residues in the extracellular domain of Human Kir2.1.

Conjugate

Application Notes

ICC/IF: 1/100 - 1/250; WB: 1/1000 - 1/10000; IHC-P: 1/250 - 1/500;

Alternative Names

KCNJ2; potassium inwardly-rectifying channel, subfamily J, member 2; inward rectifier potassium channel 2; IRK1; Kir2.1; inwardly rectifying subfamily J member 2; Cardiac inward rectifier potassium channel; HHBIRK 1; HHBIRK1; HHIRK1; HIRK 1; hIRK1; Inward

Entrez Gene ID

UniProt ID

Antigen Description

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.

Pathway

Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Classical Kir channels, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; Gastric acid secretion, organism-specific biosystem; Gastric acid secretion, cons