Anti-KCNJ2 monoclonal antibody, clone O223C/25

Antibody Isotype

IgG1

Clone

O223C/25

Species Reactivity

Mouse

Immunogen

Synthetic peptide, corresponding to C terminal amino acids 390-411 of Mouse Kir2.1 (UniProt: P35561).

Conjugate

Alternative Names

KCNJ2; potassium inwardly-rectifying channel, subfamily J, member 2; inward rectifier potassium channel 2; IRK-1; inward rectifier K(+) channel Kir2.1; potassium channel, inwardly rectifying subfamily J member 2; IRK1; Kcnf1; Kir2.1;

Entrez Gene ID

UniProt ID

Antigen Description

Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.

Pathway

Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; Gastric acid secretion, organism-specific biosystem;