Specifications
Immunogen
A synthetic peptide from the internal region of JAK2 which includes the mutation of R683G, human origin.
Applications
Application Notes
ELISA: 1:1000-1:2000
WB: 1:500-1:1000
IHC: 1:50-1:100
Target
Product Background
Antigen Description
JAK2 is a non-receptor tyrosine kinase. It is a number of the Janus kinase family and has been implicated in ssignaling by members of the type II cytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors. JAK2 orthologs have been identified in all mammals for which complete genome genome data are available. Mutations of JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders.
Pathway
AGE/RAGE pathway; ARMS-mediated activation; Adipocytokine signaling pathway; Axon guidance;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Liu, CC; Wang, SC; et al. B cells facilitate platelet production mediated by cytokines in patients with essential thrombocythaemia. THROMBOSIS AND HAEMOSTASIS 112:537-550(2014).
Bustamante, M; Fernandez-Verdejo, R; et al. Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca2+ signals and an IL-6 autocrine loop. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 306:E869-E882(2014).