Anti-JAK2 (mutation R683G) Monoclonal Antibody, clone XH074

Clone

XH074

Species Reactivity

Human

Immunogen

A synthetic peptide from the internal region of JAK2 which includes the mutation of R683G, human origin.

Conjugate

Application Notes

ELISA: 1:1000-1:2000
WB: 1:500-1:1000
IHC: 1:50-1:100

Entrez Gene ID

Antigen Description

JAK2 is a non-receptor tyrosine kinase. It is a number of the Janus kinase family and has been implicated in ssignaling by members of the type II cytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors. JAK2 orthologs have been identified in all mammals for which complete genome genome data are available. Mutations of JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders.

Pathway

AGE/RAGE pathway; ARMS-mediated activation; Adipocytokine signaling pathway; Axon guidance;